Soluble fibrin (SF) in blood consists of monomers lacking both fibrinopeptides A with a minor population in multimeric clusters. It is a substantial component of isolated fibrinogen (fg), which spontaneously self-assembles into protofibrils progressing to fibers at sub-physiologic temperatures, a process enhanced by adsorption to hydrophobic and some metal surfaces. *
In their article “Novel characteristics of soluble fibrin: hypercoagulability and acceleration of blood sedimentation rate mediated by its generation of erythrocyte-linked fibers” Dennis K. Galanakis, Anna Protopopova, Kao Li, Yingjie Yu, Tahmeena Ahmed, Lisa Senzel, Ryan Heslin, Mohamed Gouda, Jaseung Koo, John Weisel, Marilyn Manco-Johnson and Miriam Rafailovich mention how they employed topographic and lateral atomic force microscopy (AFM) scanning for imaging fg monomers and soluble polymers. Adsorption to polystyrene (PS) and to trioctylmethylamine (TOMA) coated silica wafers was used.
NANOSENSORS™ SuperSharpSilicon™SSS-SEIHR high resolution AFM probes (typical AFM tip radius of 2 nm, typical force constant 15 N/m, typical resonance frequency 130 kHz) were used for the atomic force microscopy (AFM) in tapping mode. *
Figure 5 from D. Galanakis et al. “Novel characteristics of soluble fibrin: hypercoagulability and acceleration of blood sedimentation rate mediated by its generation of erythrocyte-linked fibers”: AFM images. Horizontal bars denote 100 nm and 50 nm in panels a and b, respectively. a FR fg adsorbed on a TOMA surface showing a large, upper arrow, and a smaller multimeric cluster, lower arrow, showing the marked variation in the cluster size. The smaller cluster also shows regular surface undulations indicating its multimeric composition. b FR fg adsorbed on modified graphite (MG) surface, showing a field of solitary trinocular monomers and two clusters. Inset: a 4 × magnification from a different area of the same field showing a monomer, right arrow, and a multimeric cluster, left arrow
*Dennis K. Galanakis, Anna Protopopova, Kao Li, Yingjie Yu, Tahmeena Ahmed, Lisa Senzel, Ryan Heslin, Mohamed Gouda, Jaseung Koo, John Weisel, Marilyn Manco-Johnson and Miriam Rafailovich Novel characteristics of soluble fibrin: hypercoagulability and acceleration of blood sedimentation rate mediated by its generation of erythrocyte-linked fibers
Cell and Tissue Research 387, pages 479–491 (2022)
DOI: https://doi.org/10.1007/s00441-022-03599-9
Open Access: The article “Novel characteristics of soluble fibrin: hypercoagulability and acceleration of blood sedimentation rate mediated by its generation of erythrocyte-linked fibers” by Dennis K. Galanakis, Anna Protopopova, Kao Li, Yingjie Yu, Tahmeena Ahmed, Lisa Senzel, Ryan Heslin, Mohamed Gouda, Jaseung Koo, John Weisel, Marilyn Manco-Johnson and Miriam Rafailovich is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Discrete block co-oligomers (BCOs) can form highly ordered ultrasmall nanostructures which can be used for lithographic templates. These nanotemplates are promising for the low-cost, large-scale, and high-throughput production of sub-10 nm nanomaterials and nanodevices. However, work-intensive synthetic routes can be an obstacle to their practical application. *
In “Rapid access to discrete and monodisperse block co-oligomers from sugar and terpenoid toward ultrasmall periodic nanostructures” Takuya Isono, Ryoya Komaki, Chaehun Lee, Nao Kawakami, Bian J. Ree, Kodai Watanabe, Kohei Yoshida, Hiroaki Mamiya, Takuya Yamamoto, Redouane Borsali, Kenji Tajima and Toshifumi Satoh report the development of a readily available monodisperse and discrete block co-oligomer (BCO) system consisting of hydrophilic sugars and hydrophobic terpenoids that is capable of forming various self-assembled nanostructures with ultrasmall periodicity.*
The authors believe that the BCOs presented in their publication have the potential to contribute to accelerating applied research of solid and solution state self-assembly of discrete and monodisperse BCOs, thereby expanding their application scopes in various fields of not only the nanolithography but also organic devices, separation materials, coatings, etc.*
NANOSENSORS™ PointProbe® PlusPPP-NCHR standard tapping mode AFM probes and SuperSharpSilicon™SSS-NCHR high resolution (typical AFM tip radius 2nm) silicon AFM probes for tapping mode/non-contact mode applications were used for the atomic force microscopy (AFM) phase images presented in the article.
Fig. 4 from : Rapid access to discrete and monodisperse block co-oligomers from sugar and terpenoid toward ultrasmall periodic nanostructures by Takuya Isono et al. Thin-film morphologies of Glc3-b-Sol and Glc4-b-Sol. AFM height images (a, b) and corresponding cross-sectional profiles (c, d) indicating the formation of 6–8-nm-thick horizontal lamellae in Glc3-b-Sol (a, c) and Glc4-b-Sol thin films (b, d). Thin-film samples were prepared by spin-coating the BCO solution onto the hydrophilic surface of a silicon substrate followed by thermal annealing at 85 °C for 1 h.
*Takuya Isono, Ryoya Komaki, Chaehun Lee, Nao Kawakami, Bian J. Ree, Kodai Watanabe, Kohei Yoshida, Hiroaki Mamiya, Takuya Yamamoto, Redouane Borsali, Kenji Tajima and Toshifumi Satoh Rapid access to discrete and monodisperse block co-oligomers from sugar and terpenoid toward ultrasmall periodic nanostructures
Nature Communications Chemistry 3, 135 (2020)
DOI: https://doi.org/10.1038/s42004-020-00385-y
Open Access: The article “Rapid access to discrete and monodisperse block co-oligomers from sugar and terpenoid toward ultrasmall periodic nanostructures” by Takuya Isono, Ryoya Komaki, Chaehun Lee, Nao Kawakami, Bian J. Ree, Kodai Watanabe, Kohei Yoshida, Hiroaki Mamiya, Takuya Yamamoto, Redouane Borsali, Kenji Tajima and Toshifumi Satoh is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
The NANOSENSORS screencast on SuperSharpSilicon™ AFM probes for high resolution imaging held by Dr. Oliver Krause just passed the 500 views mark. Congratulations Oliver!
NANOSENSORS™ SuperSharpSilicon™ High Resolution AFM Probes are designed for measurements with enhanced resolution of nanostructures and microroughnesses. They are realised by a unique AFM tip manufacturing process leading to a further improvement of the AFM tip sharpness with AFM tip radii typically as low as 2 nm.
NANOSENSORS™ SuperSharpSilicon™ AFM probes are available on four different AFM cantilever types covering non-contact, acoustic or tapping mode applications as well as force modulation techniques. They are also optionally available with a magnetic coating on the AFM tip. Please have a look at the overview below.
The AFM probes of the SuperSharpSilicon™ series have stayed popular among researchers ever since their introduction and have contributed to research results presented in many published papers. You will find some literature references below. These references are just random examples. Many more published papers mentioning the use of NANOSENSORS SuperSharpSilicon™ AFM probes for high resolution atomic force microscopy imaging can be found in the usual literature repositories.
References to NANOSENSORS SuperSharpSilicon AFM probes in scientific literature:
SSS-NCHR –SuperSharpSilicon™ – Non-Contact / Tapping mode – High Resonance Frequency – Reflex Coating
So Nagashima, Sun Mi Yoon, Do Hyun Kim, Akihiro Nakatani, Myoung-Woon Moon Wrinkle-Assisted Capillary Bridging for the Directed Assembly of Single-Level DNA Nanowire Arrays
Advanced Materials Interfaces, Volume 9, Issue 6, February 22, 2022, 2102243
DOI: https://doi.org/10.1002/admi.202102243
Mario Raspanti, Marina Protasoni, Piero Antonio Zecca, Marcella Reguzzoni Slippery when wet: The free surface of the articular cartilage Microscopy Research & Technique, Volume 84, Issue 6, June 2021, Pages 1257-1264
DOI: https://doi.org/10.1002/jemt.23684
Oliver Braun, Jan Overbeck, Maria El Abbassi, Silvan Käser, Roman Furrer, Antonis Olziersky, Alexander Flasby, Gabriela Borin Barin, Qiang Sun, Rimah Darawish, Klaus Müllen, Pascal Ruffieux, Roman Fasel, Ivan Shorubalko, Mickael L. Perrin, Michel Calame Optimized graphene electrodes for contacting graphene nanoribbons
Carbon, Volume 184, 30 October 2021, Pages 331-339
DOI: https://doi.org/10.1016/j.carbon.2021.08.001
Selina Goetz, Daniella Mehanni, Neha Bansal, Bernhard Kubicek, Rachmat Adhi Wibowo, Martin Bauch, Christian Linke, Enrico Franzke, Jörg Winkler, Toby Meyer, Stephanie Narbey, David Stock, Markus Valtiner, and Theodoros Dimopoulos Low-Temperature-Processed Transparent Electrodes Based on Compact and Mesoporous Titanium Oxide Layers for Flexible Perovskite Solar Cells
ACS Applied Energy Materials 2021
DOI: https://doi.org/10.1021/acsaem.1c01129
Abeer Fahes, Aotmane En Naciri, Mohammad Navvabpour, Safi Jradi and Suzanna Akil Self-Assembled Ag Nanocomposites into Ultra-Sensitive and Reproducible Large-Area SERS-Active Opaque Substrates
Nanomaterials 2021, 11(8), 2055
DOI: https://doi.org/10.3390/nano11082055
Gaoliang Dai, Xiukun Hu, Julian Hering, Matthias Eifler, Jörg Seewig and Georg von Freymann Define and measure the dimensional accuracy of two-photon laser lithography based on its instrument transfer function
Journal of Physics: Photonics, 2021, Volume 3, Number 3 034002
DOI: https://doi.org/10.1088/2515-7647/abfaa7
Martyn Sozanskyi, Vitalii Stadnik, Pavlo Shapoval, Iosyp Yatchyshyn, Ruslana Guminilovych, Stepan Shapoval Optimization of Synthesis Conditions of Mercury Selenide Thin Films
Chemistry & Chemical Technology, 2020, Vo. 14, No 3, pp. 290 – 296
DOI: https://doi.org/10.23939/chcht14.03.290
J Jakubowcz, G Adamek, M Sopata, J K Kope and P Siwak Hot pressing of nanocrystalline tantalum using high frequency induction heating and pulse plasma sintering IOP Conference Series: Materials Science and Engineering, Volume 283, 6th Global Conference on Materials Science and Engineering 24–27 October 2017, Beijing, China, 283 012001
DOI: https://doi.org/10.1088/1757-899X/283/1/012001
Taskin Tuna, Martin Wein, Michael Swain, Jens Fischer, Wael Att Influence of ultraviolet photofunctionalization on the surface characteristics of zirconia-based dental implant materials
Dental Materials, Volume 31, Issue 2, February 2015, Pages e14-e24
DOI: https://doi.org/10.1016/j.dental.2014.10.008
D. Bergmann, B. Bodermann, H. Bosse, E. Buhr, G. Dai, R. Dixson, W. Häßler-Grohne, K. Hahm, and M. Wurm Photomask linewidth comparison by PTB and NIST
Proceedings Volume 9636, Scanning Microscopies 2015; 96360S (2015) (2 November 2015); Event: SPIE Scanning Microscopies, 2015, Monterey, California, United States
DOI: https://doi.org/10.1117/12.2199453
SSS-SEIHR – SuperSharpSilicon™ – SEIKO Microscopes – Non-Contact / Tapping Mode – High Force Constant – Reflex Coating
Jiang Yang, Tai Wang, Lina Zhao, Vinagolu K. Rajasekhar, Suhasini Joshi, Chrysafis Andreou, Suchetan Pal, Hsiao-ting Hsu, Hanwen Zhang, Ivan J. Cohen, Ruimin Huang, Ronald C. Hendrickson, Matthew M. Miele, Wenbo Pei, Matthew B. Brendel, John H. Healey, Gabriela Chiosis, and Moritz F. Kircher Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer
Nature Biomedical Engineering 4, pages 686–703 (2020)
DOI: https://doi.org/10.1038/s41551-020-0584-z
Anna D. Protopopova, Andrea Ramirez, Dmitry V. Klinov, Rustem I. Litvinov, John W. Weisel Factor XIII topology: organization of B subunits and changes with activation studied with single-molecule atomic force microscopy
Journal of Thrombosis and Haemostasis, Volume 17, Issue 5, May 2019, Pages 737-748
DOI: https://doi.org/10.1111/jth.14412
Santu Bera, Sudipta Mondal, Bin Xue, Linda J. W. Shimon, Yi Cao and Ehud Gazit Rigid helical-like assemblies from a self-aggregating tripeptide
Nature Materials volume 18, pages 503–509 (2019)
DOI: https://doi.org/10.1038/s41563-019-0343-2
Chao Liang, Zonghuang Ye, Bin Xue, Ling Zeng, Wenjian Wu, Chao Zhong, Yi Cao*, Biru Hu*, and Phillip B Messersmith Self-Assembled Nanofibers for Strong Underwater Adhesion: The Trick of Barnacles
ACS Applied Materials and Interfaces 2018, 10, 30, 25017–25025
DOI: https://doi.org/10.1021/acsami.8b04752
Anna D. Protopopova, Rustem I. Litvinov, Dennis K. Galanakis, Chandrasekaran Nagaswami, Nikolay A. Barinov, Alexander R. Mukhitov, Dmitry V. Klinov and John W. Weisela Morphometric characterization of fibrinogen’s αC regions and their role in fibrin self-assembly and molecular organization
Nanoscale. 2017 Sep 21; 9(36): 13707–13716.
DOI: 10.1039/c7nr04413e
SSS-FMR –SuperSharpSilicon™- Force Modulation Mode – Reflex Coating
Dmitry V. Bagrov, Grigory S. Glukhov, Andrey V. Moiseenko, Maria G. Karlova, Daniil S. Litvinov, Petr А. Zaitsev, Liubov I. Kozlovskaya, Anna A. Shishova, Anastasia A. Kovpak, Yury Y. Ivin, Anastasia N. Piniaeva, Alexey S. Oksanich, Viktor P. Volok, Dmitry I. Osolodkin, Aydar A. Ishmukhametov, Alexey M. Egorov, Konstantin V. Shaitan, Mikhail P. Kirpichnikov, Olga S. Sokolova Structural characterization of β-propiolactone inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) particles
Microscopy Research & Technique, Volume 85, Issue 2, February 2022, Pages 562-569
DOI: https://doi.org/10.1002/jemt.23931
P. Bampoulis Temperature induced dynamics of water confined between graphene and MoS2
The Journal of Chemical Physics 154, 134705 (2021)
DOI: https://doi.org/10.1063/5.0044123
Josué J. López, Antonio Ambrosio, Siyuan Dai, Chuong Huynh, David C. Bell, Xiao Lin, Nicholas Rivera, Shengxi Huang, Qiong Ma, Soeren Eyhusen, Ido E. Kaminer, Kenji Watanabe, Takashi Taniguchi, Jing Kong, Dimitri N. Basov, Pablo Jarillo-Herrero, Marin Soljačić Large Photothermal Effect in Sub-40 nm h-BN Nanostructures Patterned Via High-Resolution Ion Beam
Nano Micro Small, Volume 14, Issue 22, May 29, 2018, 1800072
DOI: https://doi.org/10.1002/smll.201800072
Bernhard M.Berger, Reinhard Stadlmayr, Dominic Blöch, Elisabeth Gruber, Kazuyoshi Sugiyama, Thomas Schwarz-Selinger, Friedrich Aumayr Erosion of Fe-W model system under normal and oblige D ion irradiation Nuclear Materials and Energy, Volume 12, August 2017, Pages 468-471
DOI: https://doi.org/10.1016/j.nme.2017.03.030
Wojciech Kwieciñski, Kai Sotthewes, Bene Poelsema, Harold J.W.Zandvliet, Pantelis Bampoulis Chemical vapor deposition growth of bilayer graphene in between molybdenum disulfide sheets Journal of Colloid and Interface Science, Volume 505, 1 November 2017, Pages 776-782
DOI: https://doi.org/10.1016/j.jcis.2017.06.076
SSS-MFMR – SuperSharpSilicon™ Magnetic Force Microscopy – Reflex Coating
Sai Lia, Ao Du, Yadong Wang, Xinran Wang, Xueying Zhang, Houyi Cheng, Wenlong Cai, Shiyang Lu, Kaihua Cao, Biao Pan, Na Lei, Wang Kang, Junming Liu, Albert Fert, Zhipeng Hou, Weisheng Zhao Experimental demonstration of skyrmionic magnetic tunnel junction at room temperature
Science Bulletin, Available online 15 January 2022
DOI: https://doi.org/10.1016/j.scib.2022.01.016
Martin Stückler, Christian Teichert, Aleksandar Matković, Heinz Krenn, Lukas Weissitsch, Stefan Wurster, Reinhard Pippan, AndreaBachmaier On the magnetic nanostructure of a Co–Cu alloy processed by high-pressure torsion
Journal of Science: Advanced Materials and Devices, Volume 6, Issue 1, March 2021, Pages 33-41
DOI: https://doi.org/10.1016/j.jsamd.2020.09.013
Victor G. Gisbert, Carlos A. Amo, Miriam Jaafar, Agustina Asenjo and Ricardo Garcia Quantitative mapping of magnetic properties at the nanoscale with bimodal AFM
Nanoscale, 2021, 13, 2026-2033
DOI: 10.1039/D0NR08662B
You Ba, Shihao Zhuang, Yike Zhang, Yutong Wang, Yang Gao, Hengan Zhou, Mingfeng Chen, Weideng Sun, Quan Liu, Guozhi Chai, Jing Ma, Ying Zhang, Huanfang Tian, Haifeng Du, Wanjun Jiang, Cewen Nan, Jia-Mian Hu and Yonggang Zhao Electric-field control of skyrmions in multiferroic heterostructure via magnetoelectric coupling
Nature Communications volume 12, Article number: 322 (2021)
DOI: https://doi.org/10.1038/s41467-020-20528-y
Federico Cesano, Sara Cravanzola, Valentina Brunella, Alessandro Damin and Domenica Scarano From Polymer to Magnetic Porous Carbon Spheres: Combined Microscopy, Spectroscopy, and Porosity Studies
Frontiers in Materials (2019) 6:84
DOI: https://doi.org/10.3389/fmats.2019.00084
SSS-QMFMR – SuperSharpSilicon™ – High Quality-Factor – Magnetic Force Microscopy – Reflex Coating
Peter Milde, Erik Neuber, Andreas Bauer, Christian Pfleiderer and Lukas M. Eng Surface pinning and triggered unwinding of skyrmions in a cubic chiral magnet
Physical Review B 100, 024408
DOI: https://doi.org/10.1103/PhysRevB.100.024408
Erik Neuber, Peter Milde, Adam Butykai, Sandor Bordacs, Hiroyuki Nakamura, Takeshi Waki, Yoshikazu Tabata, Korbinian Geirhos, Peter Lunkenheimer, Istvan Kézsmárki, Petr Ondrejkovic, Jirka Hlinka and Lukas M Eng Architecture of nanoscale ferroelectric domains in GaMo4S8
Journal of Physics: Condensed Matter, Volume 30, Number 44, 445402
DOI: https://doi.org/10.1088/1361-648X/aae448
N. León-Brito, E. D. Bauer, F. Ronning, J. D. Thompson, and R. Movshovicha Magnetic microstructure and magnetic properties of uniaxial itinerant ferromagnet Fe3GeTe2
Journal of Applied Physics 120, 083903 (2016)
DOI: https://doi.org/10.1063/1.4961592
I. Kézsmárki, S. Bordács, P. Milde, E. Neuber, L. M. Eng, J. S. White, H. M. Rønnow, C. D. Dewhurst, M. Mochizuki, K. Yanai, H. Nakamura, D. Ehlers, V. Tsurkan and A. Loidl Néel-type skyrmion lattice with confined orientation in the polar magnetic semiconductor GaV4S8
Nature Materials volume 14, pages 1116–1122 (2015)
DOI: https://doi.org/10.1038/nmat4402
Jeehoon Kim, N. Haberkorn, Suenne Kim, L. Civale, P. C. Dowden and R. Movshovich Ferromagnetic bubble clusters in Y0.67Ca0.33MnO3 thin films
Applied Physics Letter 102, 192409 (2013)
DOI: https://doi.org/10.1063/1.4806967
Due to their very small AFM tip radius all AFM probes of the SuperSharpSilicon™ AFM probe series need careful expert handling. The higher the aspect ratio and the smaller the tip radius of an AFM tip is the more it will be susceptible to electrostatic discharge (ESD) which can destroy the AFM tip. It is therefore important to always make sure to take all necessary precautions against electrostatic discharge (ESD) whenever you are handling these special AFM probes so that their high quality leads to the expected high resolution AFM images and the AFM tip doesn’t become damaged before it has been used. This can be achieved in the usual way by e.g. using an ESD-safe handling kit consisting of a dissipative mat, grounding wire, wrist band and helix cable with integrated safety resistors and ESD safe tweezers.
The SuperSharpSilicon™ AFM probes screencast is also available in a Chinese version “视频介绍 – SuperSharpSilicon原子力显微镜探针”on
A Japanese version of the SuperSharpSilicon AFM probe video: 超·高分解能観察用 スーパーシャープ シリコンプローブ SuperSharpSilicon” is also available on Youtube: https://youtu.be/HKK2QorNLqY
