uniqprobe

Using AFM Nanomanipulation to Investigate Nanoparticle–Substrate Adhesion

by NANOSENSORS
14 October 202614 October 2026
News & Events, Science & Technology

Multi-panel figure showing AFM topography of a selected Cu nanoparticle, its height and lateral-force response during pushing, and a schematic of the AFM manipulation sequence used to estimate nanoparticle–substrate adhesion.

At the nanoscale, the interaction between a particle and the surface beneath it can influence whether the particle remains in place or can be displaced.… Read More »Using AFM Nanomanipulation to Investigate Nanoparticle–Substrate Adhesion

Testing the Strength of Iron Oxide Nanowires with a NANOSENSORS AFM Cantilever

by NANOSENSORS
15 September 2026
News & Events, Science & Technology, Uncategorized

Fig. 1. (a) Formation process of Fe2O3 nanowires. Schematics of (b) tensile and (c) bending tests conducted on single Fe2O3 nanowires.

As nanowires become increasingly important components of sensors and other nanodevices, understanding their mechanical robustness is essential for reliable device design. In this article, Yoshinari… Read More »Testing the Strength of Iron Oxide Nanowires with a NANOSENSORS AFM Cantilever

Dynamics of Compartment-Specific Proteomic Landscapes of Hepatotoxic and Cholestatic Models of Liver Fibrosis

Atomic force microscopy (AFM) stiffness mapping reveals changes in the local mechanics of liver tissue upon hepatotoxic injury

Liver fibrosis is characterized by excessive accumulation and remodeling of extracellular matrix (ECM) components, leading to altered tissue mechanics and progressive impairment of liver function.… Read More »Dynamics of Compartment-Specific Proteomic Landscapes of Hepatotoxic and Cholestatic Models of Liver Fibrosis

Mechanical disassembly of human picobirnavirus like particles indicates that cargo retention is tuned by the RNA-coat protein interaction

by NANOSENSORS
12 February 202512 February 2025
Science & Technology

Fig. 6 from María J. Rodríguez-Espinosa et al. 2023: Model depicting the RNA cargo retention for each VLP variant. The Δ45-CP VLP structure (A) does not show externalized cargo. The CP VLP structure (B) shows shorter N-terminals compared to the Ht-CP structure (C), which implies less RNA cargo retention compared to the Ht-CP structure. The cartoons in blue, green and pink colors represent coat protein, RNA and N-terminal, respectively. For mechanical fatigue experiments, rectangular AFM cantilevers (NANOSENSORS™, uniqprobe qp-BioAC AFM probes with three different AFM cantilevers per chip) with nominal spring constants of 0.05 and 0.1 N m−1 were used. The AFM cantilevers were calibrated using Sader's method.

The idea of using virus-like particles as nanocarriers for heterologous cargo transport and delivery requires controlling the stability of the container–cargo system.* In particular, the… Read More »Mechanical disassembly of human picobirnavirus like particles indicates that cargo retention is tuned by the RNA-coat protein interaction

Deformable microlaser force sensing

by NANOSENSORS
12 September 2024
Science & Technology

Mechanical forces are key regulators of cellular behavior and function, affecting many fundamental biological processes such as cell migration, embryogenesis, immunological responses, and pathological states.… Read More »Deformable microlaser force sensing

Distinct Contact Guidance Mechanisms in Single Endothelial Cells and in Monolayers

In many tissues, cell shape and orientation are controlled by a combination of internal and external biophysical cues. * Cell shape is closely controlled in… Read More »Distinct Contact Guidance Mechanisms in Single Endothelial Cells and in Monolayers

Lipoplex-Functionalized Thin-Film Surface Coating Based on Extracellular Matrix Components as Local Gene Delivery System to Control Osteogenic Stem Cell Differentiation

Figure 5 from Catharina Husteden et al. 2023 “Lipoplex-Functionalized Thin-Film Surface Coating Based on Extracellular Matrix Components as Local Gene Delivery System to Control Osteogenic Stem Cell Differentiation”: A–D) Topography images [Cs/Col]4Cs (A), [Cs/Col]4Cs/LPX (B), [Cs/Col]4Cs/LPX/Cs (C), and [Cs/Col]4Cs/LPX/Cs/Col determined by AFM [Scale bar 1 µm] (D). E) Distribution curves of Young's modulus (E0) with a force map of a defined area (see also Figure S4, Supporting Information of the cited article). NANOSENSORSTM uniqprobe triangular qp-BioT AFM probes were used for the quantitative imaging to investigate the surface roughness and topography (in a standard liquid cell of a commercially available atomic force microscope) and force mapping. The uniqprobe qp-BioT AFM probe types offer an alternative to silicon nitride probes, with the advantage of taller AFM tips with smaller opening angles and reduced thermal drift.

The development of smart multifunctional biomaterials with the ability to control the behavior of stem cells on demand has become a powerful strategy in regenerative… Read More »Lipoplex-Functionalized Thin-Film Surface Coating Based on Extracellular Matrix Components as Local Gene Delivery System to Control Osteogenic Stem Cell Differentiation