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Accurate and rapid antibiotic susceptibility testing using a machine learning assisted nanomotion technology platform

Fig. 1 from Alexander Sturm et al. “Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform”: Nanomotion detection and recording platform. a Representation of the components of the nanomotion technology platform. b A representation of the nanomotion measurement setup with the (1) bacteria-loaded cantilever, (2) superluminescent light emitting diode (SLED) = light source, and (3) photodetector. c Schematic illustrating Gram-negative bacteria attached to the cantilever. Prior to attachment, bacteria are dispersed in gelling agarose while the cantilever surface is functionalized using positively charged poly-D-lysine. The gelling agent proved beneficial for an even distribution and stability of the bacterial attachment. d Representative standard 4-h nanomotion recordings with a 2-h medium phase (50% LB medium) followed by a 2-h drug phase with 32 µg/ml CRO for the E. coli reference strains ATCC-25922 (S, susceptible) and BAA-2452 (R, resistant). These recordings form the basis for using nanomotion to conduct AST. This study contains 219 recordings of ATCC-25922 and 225 recordings of BAA-2452 exposed to 32 µg/ml CRO with similar results. Data are available in the source data file. NANOSENSORSTM tipless uniqprobe AFM cantilevers SD-qp-CONT-TL from the NANOSENSORS Special Developments List were used.

Antimicrobial resistance (AMR) has become a significant threat to public health worldwide. * AMR diagnostic strategies such as antibiotic susceptibility testing (AST) help provide clinicians… Read More »Accurate and rapid antibiotic susceptibility testing using a machine learning assisted nanomotion technology platform

Comparative analysis of frictional behavior and mechanism of molybdenum ditelluride with different structures

Figure 3 from “Comparative analysis of frictional behavior and mechanism of molybdenum ditelluride with different structures” by Lina Zhang et al.: Atomic-scale friction maps of MoTe 2. (a) Mapping of friction signal of 1T′-MoTe 2. (b) Reciprocal lattice obtained by 2D FFT on (a). (c) Atomic-level stick–slip map obtained by FFT filtering of (a). (d) Unit cell structure of 1T′-MoTe 2. (e) Friction profile extracted along the blue dashed line in (c). (f) Mapping of friction signal of 2H-MoTe 2 . (g) Reciprocal lattice obtained by 2D FFT on (f). (h) Atomic-level stick–slip map obtained by FFT filtering of (f). (i) Unit cell structure of 2H-MoTe2. (j) Friction profile extracted along the blue dashed line in (h). NANOSENSORS PointProbe Plus PPP-LFMR AFM probes were used.

Two-dimensional (2D) transition metal dichalcogenides (TMDCs) have layered structures with excellent tribological properties. * Since the energy difference between hexagonal-molybdenum ditelluride (2H-MoTe2) and distorted octahedral-molybdenum… Read More »Comparative analysis of frictional behavior and mechanism of molybdenum ditelluride with different structures

Signal Origin of Electrochemical Strain Microscopy and Link to Local Chemical Distribution in Solid State Electrolytes

Figure 1 from Nino Schön et al. «Signal Origin of Electrochemical Strain Microscopy and Link to Local Chemical Distribution in Solid State Electrolytes”: a) Topography, b) deflection error, and c) corresponding cantilever deflection change (Dac) map of a 30 µm × 30 µm area of LATP. d) Noncontact EFM amplitude map in the same area. NANOSENSORS conductive platinum-iridium coated PointProbe Plus PPP-EFM AFM probes were used.

Solid state electrolytes (SSEs) are interesting materials that could potentially replace the currently used organic electrolytes in lithium‐ion batteries (LIBs). * Electrochemical strain microscopy (ESM),… Read More »Signal Origin of Electrochemical Strain Microscopy and Link to Local Chemical Distribution in Solid State Electrolytes