nanomotion detection

Accurate and rapid antibiotic susceptibility testing using a machine learning assisted nanomotion technology platform

Fig. 1 from Alexander Sturm et al. “Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform”: Nanomotion detection and recording platform. a Representation of the components of the nanomotion technology platform. b A representation of the nanomotion measurement setup with the (1) bacteria-loaded cantilever, (2) superluminescent light emitting diode (SLED) = light source, and (3) photodetector. c Schematic illustrating Gram-negative bacteria attached to the cantilever. Prior to attachment, bacteria are dispersed in gelling agarose while the cantilever surface is functionalized using positively charged poly-D-lysine. The gelling agent proved beneficial for an even distribution and stability of the bacterial attachment. d Representative standard 4-h nanomotion recordings with a 2-h medium phase (50% LB medium) followed by a 2-h drug phase with 32 µg/ml CRO for the E. coli reference strains ATCC-25922 (S, susceptible) and BAA-2452 (R, resistant). These recordings form the basis for using nanomotion to conduct AST. This study contains 219 recordings of ATCC-25922 and 225 recordings of BAA-2452 exposed to 32 µg/ml CRO with similar results. Data are available in the source data file. NANOSENSORSTM tipless uniqprobe AFM cantilevers SD-qp-CONT-TL from the NANOSENSORS Special Developments List were used.

Antimicrobial resistance (AMR) has become a significant threat to public health worldwide. * AMR diagnostic strategies such as antibiotic susceptibility testing (AST) help provide clinicians… Read More »Accurate and rapid antibiotic susceptibility testing using a machine learning assisted nanomotion technology platform

Celebrating 10 years NANOSENSORS Uniqprobe uniform quality AFM probes

NANOSENSORS uniqprobe AFM cantilever with partial coating

10 years ago at MRS Fall 2013 NANOSENSORS introduced the first types of the Uniqprobe – uniform quality SPM probes series. During these 10 years… Read More »Celebrating 10 years NANOSENSORS Uniqprobe uniform quality AFM probes

Yeast Nanometric Scale Oscillations Highlights Fibronectin Induced Changes in C. Albicans

by NANOSENSORS
18 October 202015 March 2023
Science & Technology

Supplementary Figure S2 from “Yeast Nanometric Scale Oscillations Highlights Fibronectin Induced Changes in C. Albicans” by Anne-Céline Kohler et al.: Density of yeast cells on AFM cantilever at the start of the experiment (A) and at the end of the experiment (B). The size of the AFM cantilever is 40 by 130 μm. NANOSENSORS tipless uniqprobe SD-qp-CONT-TL AFM probes from the NANOSENSORS Special Developments List were used in the in-house developed nanomotion detection device.

Yeast resistance to antifungal drugs is a major public health issue. Fungal adhesion onto the host mucosal surface is still a partially unknown phenomenon that… Read More »Yeast Nanometric Scale Oscillations Highlights Fibronectin Induced Changes in C. Albicans