TL-CONT

Cantilever data:
Property Nominal Value Specified Range
Resonance Frequency [kHz] 13 6 - 21
Force Constant [N/m] 0.2 0.02 - 0.77
Length [µm] 450 440 - 460
Mean Width [µm] 50 42.5 - 57.5
Thickness [µm] 2 1 - 3
Order codes and shipping units:
Order Code AFM probes per pack Data sheet
TL-CONT-10 10 of all probes
TL-CONT-20 20 of all probes
TL-CONT-50 50

Tipless - Contact Mode

NANOSENSORS™ TL-CONT sensors are designed for special applications where no AFM tip at the AFM cantilever is needed.

The AFM probe offers unique features:

  • no AFM tip
  • highly doped silicon to dissipate static charge
  • chemically inert
  • high mechanical Q-factor for high sensitivity
This AFM probe features alignment grooves on the back side of the holder chip. These grooves fit to the NANOSENSORS Alignment Chip.

Zheng Z, Lai T, Chen Y
Dependence of adhesion force on relative humidity at silica/DLC film interface
InJournal of Physics: Conference Series 2025 Jun 1 (Vol. 3030, No. 1, p. 012032). IOP Publishing
DOI: https://doi.org/10.1088/1742-6596/3030/1/012032


Mathias T, Bennewitz R, Egberts P
Mechanical property measurements enabled by short-term Fourier-transform of atomic force microscopy thermal deflection analysis
Beilstein Journal of Nanotechnology. 2025 Nov 6;16(1):1952-62
DOI: https://doi.org/10.3762/bxiv.2025.42.v1


Zheng Z, Lai T
Relative humidity dependence of adhesion force at silica-graphene interface: effect of graphene layer and contact history
The Journal of Adhesion. 2025 Apr 26:1-26
DOI: https://doi.org/10.1080/00218464.2025.2496452


Li X, Rytkin E, Zhao Q, Bhat P, Pfenniger A, Yin L, Huang X, Yang L, Yang B, Burrell A, Mikhailov A
High-resolution liquid metal–based stretchable electronics enabled by colloidal self-assembly and microtransfer printing
Science Advances. 2025 Aug 29;11(35):eadw3044
DOI: https://doi.org/10.1126/sciadv.adw3044


Chen J, Wu H, Yang W, Li H, Li Q, Li S, Liu Y, Liu F, Xu Y, Chang YZ, Himly M
AFM‐Based Deep Learning Decodes Human Macrophage Mechanophenotypes
Small Methods. 2025 Jul 28:2500953
DOI: https://doi.org/10.1002/smtd.202500953


Zhou Q, Mu L, Liu Z, Zheng S, Zhu J, Lu X
Decoupling Friction and Viscous Force at Solid–Liquid Interface via Gradient Measurement of AFM
The Journal of Physical Chemistry C. 2025 Feb 26;129(10):5209-20
DOI: https://doi.org/10.1021/acs.jpcc.4c08234


Zhang S, Su H, Lai T
Single-Layer Graphene Shields Contact Time Dependence of Adhesion Force at Silica Interfaces in Both Humid and Dry Environments
Langmuir. 2025 Aug 18;41(34):22689-701
DOI: https://doi.org/10.1021/acs.langmuir.4c04889


Han K, Ma L, Tian Y, Luo J
Photoinduced superlubricity on TiO2 surfaces
Friction. 2024 Mar;12(3):428-38
DOI: https://doi.org/10.1007/s40544-023-0736-8


Ma P, Liu Y, Han K, Tian Y, Ma L
Hydration lubrication modulated by water structure at TiO2-aqueous interfaces
Friction. 2024 Apr;12(4):591-605
DOI: https://doi.org/10.1007/s40544-023-0750-x


Zhu G, Wang Y, Wang Y, Huang H, Li B, Chen P, Chen C, Zhang H, Li Y, Liu H, Chen J
Myofibroblasts derived type V collagen promoting tissue mechanical stress and facilitating metastasis and therapy resistance of lung adenocarcinoma cells
Cell Death & Disease. 2024 Jul 10;15(7):493
DOI: https://doi.org/10.1038/s41419-024-06873-6


Jia Y, Yang Y, Zhang H
Comparative Study on the Lubrication Mechanism and Performance of Two Representative Ionic and Nonionic Self-Adhesive Polymer Coatings
Langmuir. 2024 Apr 1;40(15):8271-83
DOI: https://doi.org/10.1021/acs.langmuir.4c00539


Walker M, Pringle EW, Ciccone G, Oliver‐Cervelló L, Tassieri M, Gourdon D, Cantini M
Mind the viscous modulus: The mechanotransductive response to the viscous nature of isoelastic matrices regulates stem cell chondrogenesis
Advanced Healthcare Materials. 2024 Apr;13(9):2302571
DOI: https://doi.org/10.1002/adhm.202302571


Jia Y, Zhao Y, Zhang H
Bioinspired Self-Adhesive Multifunctional Lubricated Coating for Biomedical Implant Applications
ACS Applied Bio Materials. 2024 Jul 2;7(7):4307-22
DOI: https://doi.org/10.1021/acsabm.4c00144


Lai T, Qiu S, Wang R
Material-related and various dependences of adhesion force on piezo velocity revealed on an AFM at moderate humidity
The Journal of Adhesion. 2023 Jun 11;99(8):1402-25
DOI: https://doi.org/10.1080/00218464.2022.2122818


Lai T, Guo M, Chen Y, Zhu T
Shielding effect of hydrophobic graphene on contact time dependence of adhesion force and instability with repeated contacts at silica/silica interface
The Journal of Adhesion. 2023 Feb 17;99(3):449-72
DOI: https://doi.org/10.1080/00218464.2021.2022479


Bhuvanesh T, Nie Y, Machatschek R, Ma N, Lendlein A
Laminin–dynamic bonds enable multifunctionality in a biological 2D network
Advanced Functional Materials. 2023 Nov;33(46):2304268
DOI: https://doi.org/10.1002/adfm.202304268


Kono Y, Pack CG, Ichikawa T, Komatsubara A, Adam SA, Miyazawa K, Rolas L, Nourshargh S, Medalia O, Goldman RD, Fukuma T
Delayed localization of A-type lamins to the rupture sites in Hutchinson–Gilford progeria syndrome
bioRxiv. 2023 Sep 2:2023-09
DOI: https://doi.org/10.1101/2023.09.02.555826


Lai T, Chen Y, Zhang Y
Evolution of adhesion force behavior at the silica-HOPG interface from humidity-independent to humidity-dependent revealed on an AFM
The Journal of Adhesion. 2023 Dec 10;99(16):2402-33
DOI: https://doi.org/10.1080/00218464.2023.2185515


Xie Q, Gu R, Lin D, Liu N, Qu R, Ge F
In situ assay of interfacial interaction between ZnO nanoparticles and live cell disturbed by surfactants
Environmental Science & Technology. 2022 Sep 2;56(18):13066-75
DOI: https://doi.org/10.1021/acs.est.2c02935


Lai T, Sun J, Chen Y
Relative humidity is not a direct factor to influence adhesion force between two silica surfaces
The Journal of Adhesion. 2022 Apr 4;98(5):413-28
DOI: https://doi.org/10.1080/00218464.2020.1839429


Chen Y, Hong Z, Fan Y, Lai T
Dependence of adhesion force on contact time due to water thin-film flow revealed with an AFM cantilever at low humidity
Journal of Adhesion Science and Technology. 2022 Mar 19;36(6):620-31
DOI: https://doi.org/10.1080/01694243.2021.1932302


Li X, Chen L, Ma Y, Weng D, Li Z, Song L, Zhang X, Yu G, Wang J
Ultrafast Fabrication of Large‐Area Colloidal Crystal Micropatterns via Self‐Assembly and Transfer Printing
Advanced Functional Materials. 2022 Nov;32(45):2205462
DOI: https://doi.org/10.1002/adfm.202205462


Ichijo R, Maki K, Kabata M, Murata T, Nagasaka A, Ishihara S, Haga H, Honda T, Adachi T, Yamamoto T, Toyoshima F
Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin
Nature aging. 2022 Jul;2(7):592-600
DOI: https://doi.org/10.1038/s43587-022-00244-6


Liu Y, Li J, Li J, Yi S, Ge X, Zhang X, Luo J
Shear-induced interfacial structural conversion triggers macroscale superlubricity: From black phosphorus nanoflakes to phosphorus oxide
ACS applied materials & interfaces. 2021 Jun 30;13(27):31947-56
DOI: https://doi.org/10.1021/acsami.1c04664


Ren K, Gao J, Han D
AFM force relaxation curve reveals that the decrease of membrane tension is the essential reason for the softening of cancer cells
Frontiers in Cell and Developmental Biology. 2021 May 12;9:663021
DOI: https://doi.org/10.3389/fcell.2021.663021


Lai T, Zhu T, Chen Y, Guo M
Different evolution behaviors of adhesion force with relative humidity at silica/silica and silica/graphene interfaces studied using atomic force microscopy
Langmuir. 2021 Oct 27;37(44):13075-84
DOI: https://doi.org/10.1021/acs.langmuir.1c02221


Yamagishi A, Ito F, Nakamura C
Study on cancer cell invasiveness via application of mechanical force to induce chloride ion efflux
Analytical Chemistry. 2021 Jun 21;93(26):9032-5
DOI: https://doi.org/10.1021/acs.analchem.1c01589


Grosser S, Lippoldt J, Oswald L, Merkel M, Sussman DM, Renner F, Gottheil P, Morawetz EW, Fuhs T, Xie X, Pawlizak S
Cell and nucleus shape as an indicator of tissue fluidity in carcinoma
Physical Review X. 2021 Jan 1;11(1):011033
DOI: https://doi.org/10.1103/PhysRevX.11.011033


Lai T, Li P
Direct evidence of a radius of collection area for thin film flow in liquid bridge formation by repeated contacts using AFM
Langmuir. 2019 Apr 29;35(20):6585-93
DOI: https://doi.org/10.1021/acs.langmuir.9b00827


Feng J, Sharma S, Rao E, Li X, Zhang Q, Liao F, He J, Han D, Rao J
Stiffness heterogeneity-induced double-edged sword behaviors of carcinoma-associated fibroblasts in antitumor therapy
Science China Materials. 2019 Jun;62(6):873-84
DOI: https://doi.org/10.1007/s40843-018-9383-3


Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KS, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K.
Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
Nature Communications. 2019 Feb 28;10(1):981
DOI: https://doi.org/10.1038/s41467-019-08957-w


Lai T, Meng Y, Zhan W, Huang P
Logarithmic decrease of adhesion force with lateral dynamic revealed by an AFM cantilever at different humidities
The Journal of Adhesion. 2018 Mar 21;94(4):334-46
DOI: https://doi.org/10.1080/00218464.2016.1278532


Schulz AS, Gojzewski H, Huskens J, Vos WL, Julius Vancso G
Controlled sub‐10‐nanometer poly (N‐isopropyl‐acrylamide) layers grafted from silicon by atom transfer radical polymerization
Polymers for Advanced Technologies. 2018 Feb;29(2):806-13
DOI: https://doi.org/10.1002/pat.4187


Lai T, Meng Y
Time-dependent dynamic behaviors of a confined liquid to achieve tailored adhesion force with repeated contacts revealed by atomic force microscopy
Langmuir. 2018 Nov 25;34(50):15211-27
DOI: https://doi.org/10.1021/acs.langmuir.8b03164


Körner J, Reiche CF, Ghunaim R, Fuge R, Hampel S, Büchner B, Mühl T
Magnetic properties of individual Co2FeGa Heusler nanoparticles studied at room temperature by a highly sensitive co-resonant cantilever sensor
Scientific Reports. 2017 Aug 21;7(1):8881
DOI: https://doi.org/10.1038/s41598-017-08340-z


Ito S, Okuda S, Abe M, Fujimoto M, Onuki T, Nishimura T, Takeichi M
Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells
Nature communications. 2017 Nov 28;8(1):1834
DOI: https://doi.org/10.1038/s41467-017-01945-y


Hsiao AY, Okitsu T, Onoe H, Kiyosawa M, Teramae H, Iwanaga S, Kazama T, Matsumoto T, Takeuchi S
Smooth muscle-like tissue constructs with circumferentially oriented cells formed by the cell fiber technology
Plos one. 2015 Mar 3;10(3):e0119010
DOI: https://doi.org/10.1371/journal.pone.0119010


Rodriguez-Emmenegger C, Janel S, de los Santos Pereira A, Bruns M, Lafont F
Quantifying bacterial adhesion on antifouling polymer brushes via single-cell force spectroscopy
Polymer Chemistry. 2015;6(31):5740-51
DOI: https://doi.org/10.1039/C5PY00197H


Machida S, Watanabe-Nakayama T, Saito M, Afrin R, Ikai A
Fabricated cantilever for AFM measurements and manipulations: pre-stress analysis of stress fibers
Micron. 2012 Dec 1;43(12):1380-9
DOI: https://doi.org/10.1016/j.micron.2012.03.025


Shimizu Y, Kihara T, Haghparast SM, Yuba S, Miyake J
Simple display system of mechanical properties of cells and their dispersion
PloS one. 2012 Mar 30;7(3):e34305
DOI: https://doi.org/10.1371/journal.pone.0034305


Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, Sekiguchi K, Adachi T, Sasai Y
Self-organizing optic-cup morphogenesis in three-dimensional culture
Nature. 2011 Apr 7;472(7341):51-6
DOI: https://doi.org/10.1038/nature09941


Grigoropoulos CP, Jeon H, Hidai H, Hwang DJ
Femtosecond laser patterning of biological materials
InFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XI 2011 Feb 11 (Vol. 7925, pp. 37-45). SPIE
DOI: https://doi.org/10.1117/12.881707