The authors\nshow that distinct dietary restriction regimes and genetic pathways that\nincrease lifespan lead to radically different healthspan outcomes. Hence, their\ndata support the view that prolonged lifespan does not always coincide with\nextended healthspan. Importantly, they identify the insulin signalling pathway\nin C. elegans and interventions altering bacterial physiology as increasing\nboth lifespan and healthspan.*<\/p>\n\n\n\n
Overall,\nAFM provides a highly sensitive technique to measure organismal biomechanical\nfitness and delivers an approach to screen for health-improving conditions, an\nessential step towards healthy ageing.*<\/p>\n\n\n\n
The topographical images shown in this article were acquired using NANOSENSORS\u2122 uniqprobe<\/a> qp-CONT<\/a> AFM probes. These AFM probes have very soft cantilevers designed for imaging of biological samples ( k\u2009=\u20090.1\u2009N\/m ).<\/p>\n\n\n\n *Clara L. Essmann, Daniel Martinez-Martinez, Rosina Pryor, Kit-Yi Leung, Kalaivani Bala Krishnan, Prudence Pokway Lui, Nicholas D.E. Greene, Andr\u00e9 E.X. Brown, Vijay M. Pawar, Mandayam A. Srinivasan, Filipe Cabreiro Please follow this external link to read the full article: https:\/\/rdcu.be\/b3zb<\/a>L<\/a> <\/p>\n\n\n\n Open Access: The article \u201cMechanical properties measured by atomic force microscopy define health biomarkersin ageing C. Elegans<\/em>\u201d by Clara L. Essmann, Daniel Martinez-Martinez, Rosina Pryor, Kit-Yi Leung, Kalaivani Bala Krishnan, Prudence Pokway Lui, Nicholas D.E. Greene, Andr\u00e9 E.X. Brown, Vijay M. Pawar, Mandayam A. Srinivasan, Filipe Cabreiro is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article\u2019s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article\u2019s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http:\/\/creativecommons.org\/licenses\/by\/4.0\/. <\/p>\n","protected":false},"excerpt":{"rendered":" Genetic and environmental factors are key drivers regulating organismal lifespan but how these impact healthspan is less well understood. Techniques capturing biomechanical properties of tissues on a nano-scale level are providing new insights into disease mechanisms.* In the article \u201c Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. Elegans \u201c… Read More »Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. Elegans<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":4392,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[16],"tags":[17,448,339,398,19,449,84,456,455,454,346,450,242,313,451,452,453,221,60,109,340,447,457,50],"class_list":{"0":"post-4389","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","6":"hentry","7":"category-science-technology","8":"tag-afm-probes","9":"tag-afm","12":"tag-atomic-force-microscopy","13":"tag-biological-techniques","14":"tag-biology","15":"tag-biomechanical-fitness","16":"tag-biomechanical-properties","17":"tag-biomechanical-properties-of-tissues","18":"tag-biomechanics","19":"tag-biophysical-methods","20":"tag-biophysics","21":"tag-contact-mode-afm-probes","22":"tag-experimental-organisms","23":"tag-imaging","24":"tag-microscopy","25":"tag-qp-cont","26":"tag-scanning-probe-microscopy","27":"tag-spm-probes","28":"tag-spm","30":"tag-topography-imaging","31":"tag-uniqprobe"},"_links":{"self":[{"href":"https:\/\/www.nanosensors.com\/blog\/wp-json\/wp\/v2\/posts\/4389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nanosensors.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nanosensors.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nanosensors.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nanosensors.com\/blog\/wp-json\/wp\/v2\/comments?post=4389"}],"version-history":[{"count":0,"href":"https:\/\/www.nanosensors.com\/blog\/wp-json\/wp\/v2\/posts\/4389\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nanosensors.com\/blog\/wp-json\/wp\/v2\/media\/4392"}],"wp:attachment":[{"href":"https:\/\/www.nanosensors.com\/blog\/wp-json\/wp\/v2\/media?parent=4389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nanosensors.com\/blog\/wp-json\/wp\/v2\/categories?post=4389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nanosensors.com\/blog\/wp-json\/wp\/v2\/tags?post=4389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"https:\/\/nanosensors.com\/blog\/wp-content\/uploads\/2022\/11\/figure-1-f-from-Mechanical-properties-measured-by-atomic-force-microscopy-define-health-biomarkersin-ageing-C.-Elegans-by-Clara-L.-Essmann-et-al-2020-1024x552-2.jpg\")
f Representative AFM cuticle topography images of ageing C. elegans at different ages. <\/figcaption><\/figure>\n\n\n\n
Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. Elegans<\/strong>
Nature Communications (2020) 11:1043
DOI: https:\/\/doi.org\/10.1038\/s41467-020-14785<\/p>\n\n\n\n